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WCAV limits vasculitis. Concentrations of released ICAM-1 and VEGF were evaluated by enzyme-linked immunosorbent assay. Secretion of ICAM-1 remains low in vaccinated animals (red lines), while significantly higher in unvaccinated controls (black lines) from day 3 to day 9 post-infection challenge. The vaccinated and control groups were compared by two-way ANOVA test followed by multiplicity-adjusted post hoc comparisons (Tukey), and P -value < 0.05 was considered statistically significant (* P ≤ 0.05 and ** P ≤ 0.01).

Journal: Infection and Immunity

Article Title: Rickettsia rickettsii inactivated whole cell antigen vaccine protects against Rocky Mountain spotted fever independent of the adjuvant used

doi: 10.1128/iai.00412-25

Figure Lengend Snippet: WCAV limits vasculitis. Concentrations of released ICAM-1 and VEGF were evaluated by enzyme-linked immunosorbent assay. Secretion of ICAM-1 remains low in vaccinated animals (red lines), while significantly higher in unvaccinated controls (black lines) from day 3 to day 9 post-infection challenge. The vaccinated and control groups were compared by two-way ANOVA test followed by multiplicity-adjusted post hoc comparisons (Tukey), and P -value < 0.05 was considered statistically significant (* P ≤ 0.05 and ** P ≤ 0.01).

Article Snippet: Plasma levels of ICAM-1 were analyzed for different time points by using commercial ELISA kits (Cusabio Dog intercellular adhesion molecule 1, ICAM-1/CD54 ELISA Kit).

Techniques: Enzyme-linked Immunosorbent Assay, Infection, Control